107 Results for "

Polygala paniculata L.

" in MedChemExpress (MCE) Product Catalog:
Products (107)

107 Results for "Polygala paniculata L." in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-N0802
CAS No.: 2469-34-3
Synonyms: Senegenin
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect .
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2 Cited Publications
Cat. No.: HY-N9388
CAS No.: 82209-74-3
Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties .
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2
2 Cited Publications
Cat. No.: HY-N2099
CAS No.: 35906-36-6
Synonyms: Senegin III
Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB .
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1 Cited Publications
Cat. No.: HY-N0721
CAS No.: 27215-14-1
Synonyms: Neoandrographiside
Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates eNOS, exhibiting anti-inflammatory and hypolipidemic activity .
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1 Cited Publications
Cat. No.: HY-N0677
CAS No.: 786593-06-4
Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED50 = 386.9 mg/kg) by decreasing TXB2 levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways .
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1 Cited Publications
Cat. No.: HY-N2035
CAS No.: 3570-62-5
Moslosooflavone is a flavonoid isolated from Andrographis paniculata. Moslosooflavone has an anti-hypoxia and anti-inflammatory activities .
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1 Cited Publications
Cat. No.: HY-N8208
CAS No.: 139726-40-2
Sibiricose A1is an oligosaccharide ester that can be found in Polygala tenuifolia .
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1 Cited Publications
Cat. No.: HY-N2263
CAS No.: 93-39-0
Synonyms: Umbelliferone glucoside
Skimmin (Umbelliferone glucoside) is a major pharmacologically active and orally active molecule present in Hydrangea paniculata, a medical herb used in traditional Chinese medicine as an anti-inflammatory agent. Skimmin has renal protective activity. Skimmin can improve creatinine clearance, and reduce plasma creatinine, and kidney injuries. Skimmin has good anti-amoebic activity against the HM1:IMMS strain of Entamoeba histolytica. Skimmin has anti-cancer and neuroprotective activities. Skimmin reduces cardiac fibrosis as well as decreasing TNF-α, IL-6, IL1β, and TGFβ1 in cardiac tissues. Skimmin can be studied in research for diabetes and diabetes-related diseases .
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1 Cited Publications
Cat. No.: HY-N0857
CAS No.: 79233-15-1
Deoxyandrographolide is an orally active lactone found in the Andrographis paniculata Nees. Deoxyandrographolide shows a KD of 38.4 μM of HDAC1. Deoxyandrographolide enhances GLUT4 plasma membrane translocation, activates PI3K and AMPK-dependent signaling pathways, suppresses fasting blood glucose, serum insulin, triglycerides, and LDL-cholesterol levels. Deoxyandrographolide enhances HDAC1 expression via inhibited ubiquitination degradation, represses H3K4me3, improves chromosome stability, and restrains aging biomarkers p16, p21, γH2A.X, p53 and ROS production. Deoxyandrographolide interacts with Foot-and-Mouth Disease Virus 3Cpro active site, inhibits protease and IFN-antagonist activity, derepresses ISG expression, and inhibits viral replication. Deoxyandrographolide can be used for the researches of type 2 diabetes mellitus, vascular senescence and virus infection .
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Cat. No.: HY-W012123
CAS No.: 90-50-6
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals . 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits .
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Cat. No.: HY-N1407
CAS No.: 162857-78-5
Polygalaxanthone III is a representative xanthone component of Polygala tenuifolia. Polygalaxanthone III inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1, with an IC50 of 50.56 μM. Polygalaxanthone III repairs skin damage induced by M. furfur via activating STAT3 phosphorylation and exerts anti-inflammatory effects. Polygalaxanthone III can be used for research on M. furfur-related skin damage .
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Cat. No.: HY-N6076
CAS No.: 139726-35-5
Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells .
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Cat. No.: HY-N16690
CAS No.: 333754-86-2
3-Hydroxy-4-methoxycinnamaldehyde (compound 2) is a cinnamaldehyde from the stem bark of Flemingia paniculata Wall. 3-Hydroxy-4-methoxycinnamaldehyde exhibits antibacterial (both Gram-positive and Gram-negative) and antifungal activities (MIC = 12.5-50 μg/mL). 3-Hydroxy-4-methoxycinnamaldehyde can be used for microbial infections research .
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Cat. No.: HY-N2169
CAS No.: 162857-65-0
Polygalasaponin V is a triterpenoid saponin isolated from the aerial parts of Polygala japonica. Polygala japonica has been a folk medicine herb used as expectorant, anti-inflammatory, antibacterial and antidepressant agents in the south of China .
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Cat. No.: HY-N0801
CAS No.: 22338-71-2
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .
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Cat. No.: HY-N2498
CAS No.: 202471-84-9
Glomeratose A is a lactate dehydrogenase inhibitor, isolated from Polygala tenuifolia .
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Cat. No.: HY-N16518
CAS No.: 1494685-00-5
Andrographidine G is a new flavone glucoside. Andrographidine G can be isolated from Andrographis paniculata .
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Cat. No.: HY-N11770
CAS No.: 27875-34-9
Rhamnetin 3-O-β-D-glucopyranoside is a flavonoid, that can be isolated from the roots of Polygala sibirica L. (Polygalaceae) .
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Cat. No.: HY-N2158
CAS No.: 31002-12-7
7-O-Methylmangifer is isolated from the cortexes of Polygala tenuifolia .
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Cat. No.: HY-N6803
CAS No.: 857859-82-6
Polygalaxanthone XI, a xanthone glycoside isolated from the cortexes of Polygala tenuifolia, can be used in the study of expectorant, and tranquilizing agent .
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